Ivermectin 12 mg is a widely prescribed antiparasitic medication, often used to treat a variety of infections caused by parasitic worms and external parasites. While it's generally safe and effective, getting the dosage right is essential to ensure optimal results and prevent adverse effects. This blog explores the correct Ivermectin 12 mg dosage for various parasitic infections, how it works, and important considerations for safe use.

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What is Ivermectin 12 mg?

Ivermectin is an antiparasitic agent that works by paralyzing and killing parasites. The 12 mg dose is one of the most commonly prescribed strengths and is available in oral tablet form. It is effective against a wide range of parasites, including:

• Intestinal strongyloidiasis (Strongyloides stercoralis)

• Onchocerciasis (river blindness)

• Scabies

• Lice (head and body)

• Filariasis (lymphatic and cutaneous forms)

How Does Ivermectin Work?

Ivermectin binds to glutamate-gated chloride channels in the nerve and muscle cells of invertebrates. This increases the permeability of cell membranes to chloride ions, leading to paralysis and death of the parasite. Since human cells do not have these same receptors, the drug targets parasites specifically with minimal effects on human tissues—when taken at appropriate doses.

Correct Dosage of Ivermectin 12 mg for Common Infections

Ivermectin dosing is weight-based and tailored to the type of parasitic infection being treated. Below are general guidelines for adult patients using Ivermectin 12 mg tablets. Always consult a healthcare provider before starting treatment.

1. Strongyloidiasis (Intestinal Worms)

• Recommended Dose: 200 mcg/kg as a single dose.

• Typical Adult Dosage: One 12 mg tablet for individuals weighing between 60–70 kg.

• Repeat Dosing: Sometimes repeated after two weeks in persistent infections.

2. Onchocerciasis (River Blindness)

• Recommended Dose: 150 mcg/kg every 6 to 12 months.

• Typical Adult Dosage: One 12 mg tablet for individuals weighing 70–80 kg.

• Long-Term Plan: This condition often requires long-term intermittent treatment.

3. Scabies

• Recommended Dose: 200 mcg/kg orally, repeated after 7 to 14 days.

• Typical Adult Dosage: One 12 mg tablet per dose (for 60–70 kg adults).

• Severe or Crusted Scabies: Higher doses or multiple repeat doses may be required.

4. Lice (Pediculosis)

• Recommended Dose: 200 mcg/kg orally, repeated after 7–10 days.

• Typical Adult Dosage: One 12 mg tablet (weight dependent).

• Combination Therapy: May be used with topical treatments for better outcomes.

5. Lymphatic Filariasis

• Recommended Dose: 150–200 mcg/kg as a single annual dose.

• Typical Adult Dosage: Often one 12 mg tablet, sometimes combined with albendazole or diethylcarbamazine (DEC) depending on local guidelines.

Dosage Chart Based on Body Weight

Note: Tablets should not be split unless advised by a healthcare provider.

How to Take Ivermectin 12 mg

• Take on an empty stomach with a full glass of water (at least 1 hour before or 2 hours after a meal).

• Avoid alcohol while taking Ivermectin.

• Do not chew or crush the tablet.

• If a second dose is needed, follow the timing instructions from your healthcare provider precisely.

Who Should Not Take Ivermectin Without Medical Advice?

• Children under 15 kg or under 5 years of age.

• Pregnant or breastfeeding women (unless benefits outweigh risks).

• People with liver disease or compromised immune systems.

• Patients taking medications that interact with Ivermectin (e.g., warfarin, some anti-epileptic drugs).

Possible Side Effects

Most people tolerate Ivermectin well, but some may experience:

• Nausea or vomiting

• Dizziness or drowsiness

• Diarrhea

• Skin rash or itching

• Swelling or eye discomfort (especially in onchocerciasis patients)

Seek medical attention if you experience severe allergic reactions, confusion, seizures, or vision changes.

Conclusion

Ivermectin 12 mg is a powerful and effective treatment for several parasitic infections when taken correctly. Dosing should always be based on body weight and specific infection type. Never self-medicate—always consult a healthcare provider for personalized advice and monitoring.

Correct dosing not only ensures treatment success but also minimizes the risk of side effects and resistance. With careful administration, Ivermectin remains one of the most valuable tools in global parasitic disease control.